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In recent years, the role of Akkermansia muciniphila on the intestinal barrier has also been revealed, which improves the function of intestinal barrier by restoring the thickness of mucous layer and tight junction protein as well as producing specific antibacterial and bioactive lipids with anti-inflammatory properties [161]

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Foot flexion contracture in the rats were evaluated and graded on a scale of 0-4 with 0 being no contracture

We also found that the frequency of CD39 + CD73 + cells was increased significantly in both naive and activated GPX4-deficient CD8 + T cells (Supplemental Figure 5G), confirming further the potential relevance of adenosine signaling to T cell ferroptosis induced by GPX4 ablation